聖約翰純路跟皮膚外用藥膏？ - 芳療

A酸應該是以A醇的結構儲存在肝臟才對...=.=
找了2篇文章，一篇是文獻，一篇是書，2篇都各有引用的文獻
以下指的都是口服A酸，外用A酸似乎沒有這些困擾..

1.Ramos-e-Silva M, Hexsel DM, Rutowitsch MS, Zechmeister M. Hydroxy acids and
retinoids in cosmetics. Clin Dermatol. 2001 Jul-Aug;19(4):460-6.

463頁
Meals, particularly those with fat content, improve retinoid absorption.
Because of its lipid solubility, etretinate has extensive and prolonged
storage in fat resulting in a serum half life of 80–160 days. Upon
discontinuing the drug, a low level may be detected in the blood for 2 years
or more[1]Retinol released from the liver is carried in the circulatory
system by plasma retinol-binding proteins.

從肝臟釋放出的A醇在結束口服治療2年或更久時間後，仍有少量能在血液中被檢測到。

2.T. Krieg et al. (eds.), Therapy of Skin Diseases：A Worldwide Perspective
on Therapeutic Approaches and Their Molecular Basis, 2010

80頁
Women of childbearing potential who have been treated with acitretin must
continue using contraception for 3 years in view of its teratogenic effects
[2] .

有懷孕可能的女生在中止口服acitretin治療後，最好持續避孕3年

83頁
One major side effect of all retinoids is teratogenicity, especially in early
pregnancy which can persist for up to 2 years after cessation of orally
administered retinoids such as etretinate which may persist in the body for
several years.

所有A酸有致畸性，在口服A酸中止後，A酸留在身體裡的時間可能長達2年，etretinate甚
至可能更久。

引用文獻：
1. Saurat JH. Systemic retinoids. What's new? Dermatol Clin. 1998
Apr;16(2):331-40.
2. van de Kerkhof PC (2006) Update on retinoid therapy of psoriasis in: an
update on the use of retinoids in dermatology. Dermatol Ther 19(5):252–263

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