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http://goo.gl/keEyqo pdf檔
第34頁
Oxidation products of commonly used fragrance terpenes (limonene, linalool,
geraniol, linalyl acetate) have been identified as potent sensitisers in
predictive animal tests (119, 123-128) (see chapter 8). This is also
demonstrated for alpha-terpinene (129) and citronellol (AT Karlberg, personal
communication 2012). The oxidised fragrance terpenes limonene, linalool and
linalyl acetate have been tested in consecutive dermatitis patients and give
frequent allergic contact reactions (130-135). Not all oxidised fragrance
substances are strong sensitisers, e.g. caryophyllene is readily oxidised
but has a low sensitisation potency after autoxidation (136). This is
supported by clinical studies showing oxidised caryophyllene to be a less
frequent allergen compared to oxidised limonene and oxidised linalool (133).
Details are given in Table 5-1 The non-oxidised compounds rarely cause
allergic reactions (43-45, 67, 70, 74, 97, 137-139), for details see
Table 5-2.
As oxidised and non-oxidised fragrance terpenes were not patch tested
simultaneously in the same patients, the results are presented in two
separate tables (Table 5-1 and Table 5-2).
2012年的報告的說
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http://goo.gl/keEyqo pdf檔
第34頁
Oxidation products of commonly used fragrance terpenes (limonene, linalool,
geraniol, linalyl acetate) have been identified as potent sensitisers in
predictive animal tests (119, 123-128) (see chapter 8). This is also
demonstrated for alpha-terpinene (129) and citronellol (AT Karlberg, personal
communication 2012). The oxidised fragrance terpenes limonene, linalool and
linalyl acetate have been tested in consecutive dermatitis patients and give
frequent allergic contact reactions (130-135). Not all oxidised fragrance
substances are strong sensitisers, e.g. caryophyllene is readily oxidised
but has a low sensitisation potency after autoxidation (136). This is
supported by clinical studies showing oxidised caryophyllene to be a less
frequent allergen compared to oxidised limonene and oxidised linalool (133).
Details are given in Table 5-1 The non-oxidised compounds rarely cause
allergic reactions (43-45, 67, 70, 74, 97, 137-139), for details see
Table 5-2.
As oxidised and non-oxidised fragrance terpenes were not patch tested
simultaneously in the same patients, the results are presented in two
separate tables (Table 5-1 and Table 5-2).
2012年的報告的說
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